Protein polymorphism database dbProP is developed jointly by
NIRS (National Institute of Radiological Sciences )
and the Prime Ministerfs Millenium Project and
the Database Development Program of
Japan Science and Technology Agency
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| dbProP is supported in part by Grant-in-Aid for Publication of Scientific Research Results from Japan Society for Promotion of Science. |
What's dbProPRecently, many biological studies have started focusing on protein polymophisms. To support such studies, dbProP database provides information on amino acid polymorphisms and splicing variants found in protein coding region. "Protein polymorphism" does not only mean genetic polymorphism (amino acid substitution mainly due to SNPs) but also the ones caused by splicing in our definition, so dbProP includes alternatively spliced transcript information as well as SNPs in coding region.
Some polymorphisms that change protein quantities or structures may also affect phenotype. Since structures changed especially by amino acid substitution or alternative splicing lead to modify protein functions, you can investigate biological impacts of protein polymorphism by studying these structure changes through biochemical analysis. Protein polymorphism database dbProP has collected all kind of polymorphisms that cause amino acid substitution thoroughly. It contains data for SNPs candidates and splicing variants predicted from transcription sequence clusters in an original way, and also for SNPs extracted from the dbSNP database. dbProP positioned every SNP on mRNA and provides information on structure change in the protein being coded.
dbProP was developed to be a practical research tool. It allows retrieval of data with a variety of criteria including gene name, protein motif/domain, UniGene ID, gene database registration number, position on chromosome, absolute base range from a marker, and source tissue.
Moreover, physical relationship between amino acid substitution and protein motif domain displayed helps you examine how a polymorphism affect protein functions. PCR primers for polymorphism detection will be designed automatically on the corresponding genome or mRNA sequences.